Velosef Injection 250mg (Cefradine) — 1 Vial

Description

Velosef (250mg) Injection contains Cefradine, a first-generation cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death. It is used for treating mild to moderate bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones, and joints.

Ingredients

• Active Ingredient: Cefradine 250mg

• Excipients: Sterile additives for reconstitution

Drug Class

• First-generation Cephalosporin Antibiotic

Dosage Form

• Powder for Injection (Intravenous or Intramuscular after reconstitution)

Uses / Indications

• Respiratory tract infections (bronchitis, pneumonia, pharyngitis, tonsillitis)

• Urinary tract infections (cystitis, pyelonephritis)

• Skin and soft tissue infections (cellulitis, abscesses)

• Bone and joint infections (osteomyelitis, septic arthritis)

• ENT infections (sinusitis, otitis media)

• Septicemia and prophylaxis in surgeries

Dosage

💉 Must be administered by a healthcare professional.

• Adults:

  • 250 mg to 1 g every 6–12 hours depending on severity.

  • Severe infections: higher doses up to 8 g/day (divided).

• Children:

  • 25–50 mg/kg/day divided into 2–4 doses.

  • Severe infections: up to 100 mg/kg/day.

• Renal impairment: Dose adjustment required.

In Case of Overdose

• Symptoms: Nausea, vomiting, diarrhea, possible seizures (rare).

• Management: Stop drug, provide supportive treatment, hemodialysis may help.

Missed Dose

• Take as soon as remembered.

• Skip if close to the next dose.

• Do not double the dose.

How To Use

• Reconstitute the vial with sterile water for injection or compatible IV solution.

• Administer by intramuscular (IM) injection or intravenous (IV) injection/infusion.

• Only under medical supervision.

When Not to Use / Contraindications

• Known allergy to cephalosporins, penicillins, or other beta-lactam antibiotics

• Severe renal impairment (without dose adjustment)

• History of severe allergic reactions (e.g., anaphylaxis)

Side Effects

Common:

• Pain, swelling, or redness at injection site

• Nausea, vomiting, diarrhea

• Rash or itching

Serious (rare):

• Severe allergic reaction (anaphylaxis)

• Stevens–Johnson syndrome (serious skin reaction)

• Seizures (in high doses with renal impairment)

• Blood disorders (low WBC, platelet count, or anemia)

Precautions & Warnings

• Use with caution in patients with kidney disease

• Cross-sensitivity possible with penicillin

• Long-term use may cause fungal or yeast overgrowth

• Pregnancy: Use only if prescribed by doctor

• Breastfeeding: Passes into milk in small amounts, caution advised

Drug Interactions

• Aminoglycosides (e.g., gentamicin): ↑ risk of kidney damage

• Diuretics (furosemide, ethacrynic acid): ↑ nephrotoxicity risk

• Oral anticoagulants (e.g., warfarin): ↑ bleeding risk

• Other antibiotics: May alter effectiveness

Storage / Disposal

• Store below 25°C in a dry place, away from sunlight

• Keep in original packaging until use

• Use reconstituted solution immediately

• Discard unused solution safely according to local medical waste rules

Control Drug / Prescription Status

• Prescription-only medicine

Quick Tips

• Complete the full antibiotic course, even if symptoms improve early

• Inform doctor if allergic to cephalosporins or penicillins

• Report severe diarrhea (may indicate Clostridium difficile infection)

• Drink plenty of fluids unless restricted